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At 72 weeks, tirzepatide vs semaglutide produced 20.2% mean weight loss versus 13.7% in SURMOUNT-5, the first randomized head-to-head trial between them (NEJM, May 2025)
Drug levels stayed stable in the blood for a week, pointing to the potential for a once-weekly, high-dose patch, and the delivery profile closely matched that of an injection, a critical factor for commercial viability, Daewoong said
The origin of the increase in lymphocytes starting 3 h after the immune challenge cannot be conclusively determined